Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice
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چکیده
منابع مشابه
Cell adhesion molecules involved in the leukocyte recruitment induced by venom of the snake Bothrops jararaca.
It has been shown that Bothrops jararaca venom (BjV) induces a significant leukocyte accumulation, mainly neutrophils, at the local of tissue damage. Therefore, the role of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), LECAM-1, CD18, leukocyte function-associated antigen-1 (LFA-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) on the BjV-induced neutrophil accu...
متن کاملAntitumor effect of Bothrops jararaca venom.
Many experimental studies have been carried out using snake venoms for the treatment of animal tumors, with controversial results. While some authors have reported an antitumor effect of treatment with specific snake venom fractions, others have reported no effects after this treatment. The aim of this study was to evaluate the effect of Bothrops jararaca venom (BjV) on Ehrlich ascites tumor (E...
متن کاملThe humoral immune responses of patients bitten by the snake Bothrops jararaca (jararaca).
The isotype and specificity of antibodies produced by patients bitten by B. jararaca and submitted to serum therapy were studied. The IgG anti-B. jararaca antibodies have large individual dispersion, starting to appear 10 days after the first bite and increasing to at least 80 days after the bite. IgM antibodies appeared sooner than IgG antibodies but disappeared about 20 days after the bite. S...
متن کاملLocal and systemic biochemical alterations induced by Bothrops atrox snake venom in mice
The local and systemic alterations induced by Bothrops atrox snake venom (BaV) injection in mice were studied. BaV induced superoxide production by migrated neutrophils, mast cell degranulation and phagocytosis by macrophages. Moreover, BaV caused hemorrhage in dorsum of mice after 2hr post- injection. Three hours post-injection in gastrocnemius muscle, we also observed myonecrosis, which was a...
متن کاملHemostatic properties of Venezuelan Bothrops snake venoms with special reference to Bothrops isabelae venom.
In Venezuela, Bothrops snakes are responsible for more than 80% of all recorded snakebites. This study focuses on the biological and hemostatic characteristics of Bothrops isabelae venom along with its comparative characteristics with two other closely related Bothrops venoms, Bothrops atrox and Bothrops colombiensis. Electrophoretic profiles of crude B. isabelae venom showed protein bands betw...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2018
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0006774